diff --git a/python/sglang/srt/hardware_backend/npu/utils.py b/python/sglang/srt/hardware_backend/npu/utils.py
index cdc5ad2fd..49332ccf4 100644
--- a/python/sglang/srt/hardware_backend/npu/utils.py
+++ b/python/sglang/srt/hardware_backend/npu/utils.py
@@ -107,6 +107,28 @@ def init_npu_backend():
     torch_npu.npu.set_compile_mode(jit_compile=False)
 
 
+def _is_nz_aligned(tensor: torch.Tensor) -> bool:
+    """Check whether the last two dims satisfy FRACTAL_NZ alignment rules.
+
+    Ascend FRACTAL_NZ requires:
+      BF16 / FP16 : both dims divisible by 16
+      INT8         : k % 16 == 0  and  n % 32 == 0
+      INT4         : k % 16 == 0  and  n % 64 == 0
+      FP4          : both dims divisible by 64
+    """
+    if tensor.dim() < 2:
+        return False
+    k, n = tensor.shape[-2], tensor.shape[-1]
+    if tensor.dtype in (torch.bfloat16, torch.float16):
+        return k % 16 == 0 and n % 16 == 0
+    if tensor.dtype == torch.int8:
+        return k % 16 == 0 and n % 32 == 0
+    if tensor.dtype in (torch.uint8, torch.int32):
+        # INT4 is typically packed into uint8/int32; be conservative
+        return k % 16 == 0 and n % 64 == 0
+    return True
+
+
 def npu_format_cast(
     tensor: torch.Tensor,
     acl_format: NPUACLFormat = NPUACLFormat.ACL_FORMAT_FRACTAL_NZ,
@@ -135,8 +157,20 @@ def npu_format_cast(
             "significantly reduced."
         )
         return tensor
-    else:
-        return torch.ops.npu.npu_format_cast(tensor, acl_format.value)
+
+    if acl_format == NPUACLFormat.ACL_FORMAT_FRACTAL_NZ and not _is_nz_aligned(tensor):
+        k, n = tensor.shape[-2], tensor.shape[-1]
+        logger.warning_once(
+            "Skipping FRACTAL_NZ format cast: tensor shape (%d, %d) dtype %s "
+            "is not aligned to NZ requirements. Falling back to 'ND' format, "
+            "which may reduce NPU performance.",
+            k,
+            n,
+            tensor.dtype,
+        )
+        return tensor
+
+    return torch.ops.npu.npu_format_cast(tensor, acl_format.value)
 
 
 def get_indexer_weight_stream():
diff --git a/python/sglang/srt/layers/quantization/unquant.py b/python/sglang/srt/layers/quantization/unquant.py
index 9fcb88e54..5c2f489e9 100644
--- a/python/sglang/srt/layers/quantization/unquant.py
+++ b/python/sglang/srt/layers/quantization/unquant.py
@@ -317,9 +317,7 @@ class UnquantizedFusedMoEMethod(FusedMoEMethodBase, MultiPlatformOp):
             for weight_name in ["w13_weight", "w2_weight"]:
                 weight = getattr(layer, weight_name)
                 weight.data = weight.data.transpose(1, 2)
-                weight.data = npu_format_cast(
-                    weight.data,
-                )
+                weight.data = npu_format_cast(weight.data)
 
         return