diff --git a/python/sglang/kernels/aot/csrc/allreduce/quick_all_reduce_base.h b/python/sglang/kernels/aot/csrc/allreduce/quick_all_reduce_base.h
index 759b28f38..c22a7fb3e 100644
--- a/python/sglang/kernels/aot/csrc/allreduce/quick_all_reduce_base.h
+++ b/python/sglang/kernels/aot/csrc/allreduce/quick_all_reduce_base.h
@@ -77,12 +77,23 @@ union BufferResource {
   };
 };
 
+// llvm.amdgcn.raw.buffer.* instructions do not exist on RDNA4 (gfx12).
+// QuickReduce remains runtime-disabled on gfx1250; these stubs only allow the
+// shared ROCm extension to compile for that target.
+#if !defined(__gfx1250__)
 __quickreduce_device_inline__ static int32x4_t buffer_load_dwordx4(
     int32x4_t srsrc, int32_t voffset, int32_t soffset, int32_t aux) __asm("llvm.amdgcn.raw.buffer.load.v4i32");
 
 __quickreduce_device_inline__ static void
 buffer_store_dwordx4(int32x4_t data, int32x4_t srsrc, int32_t voffset, int32_t soffset, int32_t aux) __asm(
     "llvm.amdgcn.raw.buffer.store.v4i32");
+#else
+__quickreduce_device_inline__ static int32x4_t
+buffer_load_dwordx4(int32x4_t srsrc, int32_t voffset, int32_t soffset, int32_t aux) {}
+
+__quickreduce_device_inline__ static void
+buffer_store_dwordx4(int32x4_t data, int32x4_t srsrc, int32_t voffset, int32_t soffset, int32_t aux) {}
+#endif
 
 __quickreduce_device_inline__ static void set_fp16_ovfl(bool const value) {
 #if defined(__gfx942__)
diff --git a/python/sglang/kernels/aot/setup_rocm.py b/python/sglang/kernels/aot/setup_rocm.py
index 9762787aa..289683910 100644
--- a/python/sglang/kernels/aot/setup_rocm.py
+++ b/python/sglang/kernels/aot/setup_rocm.py
@@ -74,9 +74,9 @@ if torch.cuda.is_available():
 else:
     print(f"Warning: torch.cuda not available. Using default target: {amdgpu_target}")
 
-if amdgpu_target not in ["gfx942", "gfx950"]:
+if amdgpu_target not in ["gfx942", "gfx950", "gfx1250"]:
     print(
-        f"Warning: Unsupported GPU architecture detected '{amdgpu_target}'. Expected 'gfx942' or 'gfx950'."
+        f"Warning: Unsupported GPU architecture detected '{amdgpu_target}'. Expected 'gfx942', 'gfx950', or 'gfx1250'."
     )
     sys.exit(1)
 
@@ -87,7 +87,7 @@ fp8_macro = (
 # Dynamic shared-memory budget for the TopK kernels.
 # - gfx942 (MI300/MI325): LDS is typically 64KB per workgroup -> keep dynamic smem <= ~48KB
 #   (leaves room for static shared allocations in the kernel).
-# - gfx95x (MI350): LDS is larger (e.g. 160KB per CU) -> allow the original 128KB dynamic smem.
+# - gfx95x (MI350) and gfx1250: LDS is larger -> allow the original 128KB dynamic smem.
 topk_dynamic_smem_bytes = 48 * 1024 if amdgpu_target == "gfx942" else 32 * 1024 * 4
 
 hipcc_flags = [
@@ -126,5 +126,4 @@ setup(
     package_dir={"": "python"},
     ext_modules=ext_modules,
     cmdclass={"build_ext": BuildExtension.with_options(use_ninja=True)},
-    options={"bdist_wheel": {"py_limited_api": "cp39"}},
 )