diff --git a/docs/cookbook/diffusion/MiniMax/MiniMax-H3.mdx b/docs/cookbook/diffusion/MiniMax/MiniMax-H3.mdx
index 278f569c6..9b7b032e8 100644
--- a/docs/cookbook/diffusion/MiniMax/MiniMax-H3.mdx
+++ b/docs/cookbook/diffusion/MiniMax/MiniMax-H3.mdx
@@ -314,6 +314,12 @@ honors each layer's activation mode; omit `--quantization`.
 Mixed exports use the same command: SGLang dispatches each marked layer to its
 serialized W4A4 or INT8 ConvRot kernel instead of applying one global method.
 
+Comfy NVFP4 DiTs reuse SGLang's ModelOpt NVFP4 backend, which requires CUDA
+compute capability 10.0 or newer. Pass a pruned FL2VA / Ref2VA file such as
+`Abiray/Minimax-H3-nvfp4-INT4-INT8-Convrot/MiniMax_H3_FL2VA_pruned_nvfp4.safetensors`
+to `--transformer-weights-path` and omit `--quantization`. SGLang infers the
+packed group size and Comfy scale layout from the checkpoint; FSDP is rejected.
+
 ### Advanced: precomputed AdaLN cache
 
 The [model card](https://huggingface.co/MiniMaxAI/MiniMax-H3) notes that about
diff --git a/docs/docs/sglang-diffusion/quantization.mdx b/docs/docs/sglang-diffusion/quantization.mdx
index 136dc9d69..8a0faae09 100644
--- a/docs/docs/sglang-diffusion/quantization.mdx
+++ b/docs/docs/sglang-diffusion/quantization.mdx
@@ -154,11 +154,11 @@ backend.
     </tr>
     <tr>
       <td><code>modelopt-nvfp4</code></td>
-      <td>Mixed transformer directory/repo with <code>config.json</code>, raw NVFP4 safetensors export/repo, or full ModelOpt Diffusers repo</td>
+      <td>Mixed transformer directory/repo with <code>config.json</code>, raw or Comfy layer-marked NVFP4 safetensors, or full ModelOpt Diffusers repo</td>
       <td><code>--transformer-path</code> for mixed overrides; <code>--transformer-weights-path</code> for raw exports; <code>--model-path</code> for full repos</td>
-      <td>FLUX.1, FLUX.2, Wan2.2, Qwen Image, Qwen Image 2512, Qwen Image Edit, Qwen Image Edit 2511</td>
+      <td>FLUX.1, FLUX.2, Wan2.2, Qwen Image, Qwen Image 2512, Qwen Image Edit, Qwen Image Edit 2511, MiniMax-H3</td>
       <td>None</td>
-      <td>Mixed override repos keep the base model separate; full Qwen Image exports can be loaded directly as <code>--model-path</code>; raw exports such as <code>black-forest-labs/FLUX.2-dev-NVFP4</code> still use the weights-path flow</td>
+      <td>Mixed override repos keep the base model separate; full Qwen Image exports can be loaded directly as <code>--model-path</code>; raw exports such as <code>black-forest-labs/FLUX.2-dev-NVFP4</code> use the weights-path flow. Comfy markers select their checkpoint layout automatically; omit <code>--quantization</code>.</td>
     </tr>
     <tr>
       <td><code>gguf</code></td>
diff --git a/python/sglang/multimodal_gen/runtime/layers/quantization/configs/base_config.py b/python/sglang/multimodal_gen/runtime/layers/quantization/configs/base_config.py
index cdbca71fc..a2adaeb6e 100644
--- a/python/sglang/multimodal_gen/runtime/layers/quantization/configs/base_config.py
+++ b/python/sglang/multimodal_gen/runtime/layers/quantization/configs/base_config.py
@@ -36,6 +36,7 @@ class QuantizationConfig(SRTQuantizationConfig):
     # for quantization frameworks with a separate quantized model provided, e.g. Nunchaku
     quantized_model_path: str | None = None
     checkpoint_uses_native_qkv_layout: bool = False
+    checkpoint_uses_comfy_quantization: bool = False
     supports_srt_linear_layers: bool = False
 
     def get_scaled_act_names(self) -> list[str]:
diff --git a/python/sglang/multimodal_gen/runtime/layers/quantization/modelopt_quant.py b/python/sglang/multimodal_gen/runtime/layers/quantization/modelopt_quant.py
index a6c7b80a8..b10c5aa12 100755
--- a/python/sglang/multimodal_gen/runtime/layers/quantization/modelopt_quant.py
+++ b/python/sglang/multimodal_gen/runtime/layers/quantization/modelopt_quant.py
@@ -236,6 +236,7 @@ class ModelOptFp4Config(ModelOptQuantConfig):
         checkpoint_uses_packed_qkv: bool = False,
         swap_weight_nibbles: bool = False,
         checkpoint_weight_scale_layout: str = "linear",
+        checkpoint_uses_comfy_quantization: bool = False,
     ) -> None:
         super().__init__(exclude_modules, packed_modules_mapping)
         self.is_checkpoint_nvfp4_serialized = is_checkpoint_nvfp4_serialized
@@ -248,6 +249,7 @@ class ModelOptFp4Config(ModelOptQuantConfig):
         self.checkpoint_uses_packed_qkv = checkpoint_uses_packed_qkv
         self.swap_weight_nibbles = swap_weight_nibbles
         self.checkpoint_weight_scale_layout = checkpoint_weight_scale_layout
+        self.checkpoint_uses_comfy_quantization = checkpoint_uses_comfy_quantization
 
     @classmethod
     def get_name(cls) -> str:
@@ -348,6 +350,9 @@ class ModelOptFp4Config(ModelOptQuantConfig):
             checkpoint_weight_scale_layout=config.get(
                 "checkpoint_weight_scale_layout", "linear"
             ),
+            checkpoint_uses_comfy_quantization=config.get(
+                "checkpoint_uses_comfy_quantization", False
+            ),
         )
 
     def get_quant_method(self, layer: torch.nn.Module, prefix: str):
diff --git a/python/sglang/multimodal_gen/runtime/loader/component_loaders/transformer_loader.py b/python/sglang/multimodal_gen/runtime/loader/component_loaders/transformer_loader.py
index 251dc6bad..34d0eda5d 100644
--- a/python/sglang/multimodal_gen/runtime/loader/component_loaders/transformer_loader.py
+++ b/python/sglang/multimodal_gen/runtime/loader/component_loaders/transformer_loader.py
@@ -248,7 +248,10 @@ class TransformerLoader(ComponentLoader):
                     safetensors_list
                 )
                 checkpoint_quant_config = resolve_minimax_h3_checkpoint_quantization(
-                    layer_markers
+                    layer_markers,
+                    safetensors_list,
+                    dit_config.arch_config.param_names_mapping,
+                    dit_config.arch_config.reverse_param_names_mapping,
                 )
                 if adaln_curve_shape is not None:
                     (
diff --git a/python/sglang/multimodal_gen/runtime/loader/minimax_h3_weights.py b/python/sglang/multimodal_gen/runtime/loader/minimax_h3_weights.py
index 7afda25a9..ad9059c05 100644
--- a/python/sglang/multimodal_gen/runtime/loader/minimax_h3_weights.py
+++ b/python/sglang/multimodal_gen/runtime/loader/minimax_h3_weights.py
@@ -9,6 +9,7 @@ from sglang.multimodal_gen.runtime.layers.quantization.configs.base_config impor
     QuantizationConfig,
 )
 from sglang.multimodal_gen.runtime.utils.quantization_utils import (
+    build_nvfp4_config_from_safetensors_list,
     inspect_comfy_quant_markers,
     resolve_comfy_checkpoint_quantization,
 )
@@ -47,7 +48,26 @@ def inspect_minimax_h3_safetensors(
 
 def resolve_minimax_h3_checkpoint_quantization(
     layer_markers: dict[str, dict[str, Any]],
+    safetensors_list: list[str] | None = None,
+    param_names_mapping: dict | None = None,
+    reverse_param_names_mapping: dict | None = None,
 ) -> QuantizationConfig | None:
+    formats = {str(marker.get("format")) for marker in layer_markers.values()}
+    if formats == {"nvfp4"}:
+        if safetensors_list is None:
+            raise ValueError("MiniMax-H3 NVFP4 metadata requires checkpoint files")
+        config = build_nvfp4_config_from_safetensors_list(
+            safetensors_list,
+            param_names_mapping,
+            reverse_param_names_mapping,
+        )
+        if config is None:
+            raise ValueError("Could not resolve MiniMax-H3 NVFP4 checkpoint layout")
+        config.checkpoint_uses_comfy_quantization = True
+        config.checkpoint_uses_native_qkv_layout = True
+        config.checkpoint_weight_scale_layout = "swizzled"
+        config.swap_weight_nibbles = True
+        return config
     return resolve_comfy_checkpoint_quantization(layer_markers)
 
 
diff --git a/python/sglang/multimodal_gen/runtime/loader/transformer_load_utils.py b/python/sglang/multimodal_gen/runtime/loader/transformer_load_utils.py
index f98a89a26..3216ce3bc 100644
--- a/python/sglang/multimodal_gen/runtime/loader/transformer_load_utils.py
+++ b/python/sglang/multimodal_gen/runtime/loader/transformer_load_utils.py
@@ -141,6 +141,14 @@ def _merge_modelopt_fp4_configs(
     )
     if getattr(inferred_config, "group_size", None) is None:
         inferred_config.group_size = getattr(existing_config, "group_size", None)
+    inferred_config.checkpoint_uses_comfy_quantization = (
+        inferred_config.checkpoint_uses_comfy_quantization
+        or existing_config.checkpoint_uses_comfy_quantization
+    )
+    inferred_config.checkpoint_uses_native_qkv_layout = (
+        inferred_config.checkpoint_uses_native_qkv_layout
+        or existing_config.checkpoint_uses_native_qkv_layout
+    )
 
     return inferred_config
 
@@ -194,6 +202,10 @@ class TransformerQuantLoadSpec:
             or self.is_serialized_kitchen_int8
             or self.is_serialized_kitchen_w4a4
             or self.is_serialized_kitchen_w4a8
+            or (
+                self.quant_config is not None
+                and self.quant_config.checkpoint_uses_comfy_quantization
+            )
             or (
                 _get_quant_config_name(self.quant_config) == "mxfp8"
                 and self.quant_config.layer_markers is not None
diff --git a/python/sglang/multimodal_gen/runtime/utils/quantization_utils.py b/python/sglang/multimodal_gen/runtime/utils/quantization_utils.py
index dd91f4a20..62e11954b 100644
--- a/python/sglang/multimodal_gen/runtime/utils/quantization_utils.py
+++ b/python/sglang/multimodal_gen/runtime/utils/quantization_utils.py
@@ -674,11 +674,12 @@ def _build_nvfp4_config_from_safetensors_files(
             and "layers" in quant_config_dict
         ):
             layers = quant_config_dict.get("layers", {})
-            file_quantized_modules.update(
+            metadata_nvfp4_modules = {
                 layer_name
                 for layer_name, layer_cfg in layers.items()
                 if isinstance(layer_cfg, dict) and layer_cfg.get("format") == "nvfp4"
-            )
+            }
+            file_quantized_modules.update(metadata_nvfp4_modules)
 
         tensor_metadata = _read_safetensors_tensor_metadata(file_path)
         with safe_open(file_path, framework="pt", device="cpu") as f:
@@ -815,6 +816,7 @@ def _build_nvfp4_config_from_safetensors_files(
                     "swizzled" if checkpoint_uses_swizzled_scales else "linear"
                 ),
                 "swap_weight_nibbles": checkpoint_uses_swizzled_scales,
+                "checkpoint_uses_comfy_quantization": checkpoint_uses_comfy_quant,
             }
         )
         logger.info(
diff --git a/python/sglang/multimodal_gen/test/unit/test_transformer_quant.py b/python/sglang/multimodal_gen/test/unit/test_transformer_quant.py
index 55801716c..ebf124ae3 100644
--- a/python/sglang/multimodal_gen/test/unit/test_transformer_quant.py
+++ b/python/sglang/multimodal_gen/test/unit/test_transformer_quant.py
@@ -1105,6 +1105,16 @@ class TestTransformerQuantHelpers(unittest.TestCase):
         self.assertTrue(config.load_in_4bit)
 
     def test_nvfp4_safetensors_inference_ignores_fp8_fallback_scales(self):
+        metadata = {
+            "_quantization_metadata": json.dumps(
+                {
+                    "format_version": "1.0",
+                    "layers": {
+                        "layers.0.attention.qkv": {"format": "nvfp4"},
+                    },
+                }
+            )
+        }
         with tempfile.NamedTemporaryFile(suffix=".safetensors") as f:
             save_file(
                 {
@@ -1127,6 +1137,7 @@ class TestTransformerQuantHelpers(unittest.TestCase):
                     ),
                 },
                 f.name,
+                metadata=metadata,
             )
 
             config = build_nvfp4_config_from_safetensors_list([f.name])
@@ -1137,6 +1148,7 @@ class TestTransformerQuantHelpers(unittest.TestCase):
         self.assertNotIn("layers.0.attention.qkv", config.exclude_modules)
         self.assertEqual(config.checkpoint_weight_scale_layout, "linear")
         self.assertFalse(config.swap_weight_nibbles)
+        self.assertFalse(config.checkpoint_uses_comfy_quantization)
 
     def test_nvfp4_safetensors_inference_uses_comfy_checkpoint_layout(self):
         with tempfile.NamedTemporaryFile(suffix=".safetensors") as f:
@@ -1179,6 +1191,62 @@ class TestTransformerQuantHelpers(unittest.TestCase):
         self.assertNotIn("layers.0.attention.qkv", config.exclude_modules)
         self.assertEqual(config.checkpoint_weight_scale_layout, "swizzled")
         self.assertTrue(config.swap_weight_nibbles)
+        self.assertTrue(config.checkpoint_uses_comfy_quantization)
+        self.assertFalse(config.checkpoint_uses_native_qkv_layout)
+        spec = TransformerQuantLoadSpec(
+            safetensors_list=[f.name],
+            quant_config=config,
+            nunchaku_config=None,
+            param_dtype=None,
+        )
+        self.assertTrue(spec.uses_comfy_layer_markers)
+
+    def test_minimax_h3_comfy_nvfp4_resolves_modelopt_backend(self):
+        metadata = {
+            "_quantization_metadata": json.dumps(
+                {
+                    "format_version": "1.0",
+                    "layers": {
+                        "blocks.0.attn.qkv_proj": {"format": "nvfp4"},
+                    },
+                }
+            )
+        }
+        with (
+            tempfile.NamedTemporaryFile(suffix=".safetensors") as quantized,
+            tempfile.NamedTemporaryFile(suffix=".safetensors") as fallback,
+        ):
+            save_file(
+                {
+                    "blocks.0.attn.qkv_proj.weight": torch.zeros(
+                        (32, 8), dtype=torch.uint8
+                    ),
+                    "blocks.0.attn.qkv_proj.weight_scale": torch.ones(
+                        (32, 1), dtype=torch.float8_e4m3fn
+                    ),
+                    "blocks.0.attn.qkv_proj.weight_scale_2": torch.tensor(1.0),
+                },
+                quantized.name,
+                metadata=metadata,
+            )
+            save_file(
+                {"blocks.0.mlp.fc1.weight": torch.ones((2, 2))},
+                fallback.name,
+            )
+            checkpoint_files = [quantized.name, fallback.name]
+            _, markers = inspect_minimax_h3_safetensors(checkpoint_files)
+            config = resolve_minimax_h3_checkpoint_quantization(
+                markers,
+                checkpoint_files,
+            )
+
+        self.assertIsInstance(config, ModelOptFp4Config)
+        self.assertEqual(config.group_size, 16)
+        self.assertIn("blocks.0.mlp.fc1", config.exclude_modules)
+        self.assertTrue(config.checkpoint_uses_comfy_quantization)
+        self.assertTrue(config.checkpoint_uses_native_qkv_layout)
+        self.assertEqual(config.checkpoint_weight_scale_layout, "swizzled")
+        self.assertTrue(config.swap_weight_nibbles)
 
     def test_builder_adds_diffusers_quant_type_for_nvfp4(self):
         updated = _updated_quant_config(