diff --git a/python/sglang/srt/layers/moe/fused_moe_triton/layer.py b/python/sglang/srt/layers/moe/fused_moe_triton/layer.py
index db10d3ce4..aad266166 100644
--- a/python/sglang/srt/layers/moe/fused_moe_triton/layer.py
+++ b/python/sglang/srt/layers/moe/fused_moe_triton/layer.py
@@ -803,6 +803,16 @@ class FusedMoE(torch.nn.Module):
                 param=param,
                 weight_name=weight_name,
             )
+        elif isinstance(method, Fp8MoEMethod) and (
+            get_moe_runner_backend().is_flashinfer_trtllm_routed()
+            or get_moe_runner_backend().is_flashinfer_trtllm()
+        ):
+            # Drop the GPU mxfp8 shuffle-index cache on every reload for mxfp8 trtllm, trtllm_routed
+            from sglang.srt.layers.moe.moe_runner.flashinfer_trtllm import (
+                clear_mxfp8_shuffle_index_cache,
+            )
+
+            clear_mxfp8_shuffle_index_cache()
 
         loaded_weight = (
             loaded_weight.t().contiguous()
@@ -1025,6 +1035,16 @@ class FusedMoE(torch.nn.Module):
         method = self.quant_method
         if hasattr(self, "scheme"):
             method = self.scheme
+        if isinstance(method, Fp8MoEMethod) and (
+            get_moe_runner_backend().is_flashinfer_trtllm_routed()
+            or get_moe_runner_backend().is_flashinfer_trtllm()
+        ):
+            # Drop the GPU mxfp8 shuffle-index cache on every reload for mxfp8 trtllm, trtllm_routed
+            from sglang.srt.layers.moe.moe_runner.flashinfer_trtllm import (
+                clear_mxfp8_shuffle_index_cache,
+            )
+
+            clear_mxfp8_shuffle_index_cache()
         loaded_weight = (
             loaded_weight.t().contiguous()
             if (
diff --git a/python/sglang/srt/layers/moe/moe_runner/flashinfer_trtllm.py b/python/sglang/srt/layers/moe/moe_runner/flashinfer_trtllm.py
index 5c80dc22d..19a1df20f 100644
--- a/python/sglang/srt/layers/moe/moe_runner/flashinfer_trtllm.py
+++ b/python/sglang/srt/layers/moe/moe_runner/flashinfer_trtllm.py
@@ -113,6 +113,14 @@ _flashinfer_trtllm_shuffle_row_indices_cache_mxfp8: dict[
 ] = {}
 
 
+def clear_mxfp8_shuffle_index_cache() -> None:
+    """Drop the cached MXFP8 MoE row-index permutations.
+    The cached index tensors are GPU-resident; sglang reuses the weights-region
+    memory across weight-update cycles
+    """
+    _flashinfer_trtllm_shuffle_row_indices_cache_mxfp8.clear()
+
+
 def _is_gated(layer: Module) -> bool:
     """Return whether the MoE layer uses a gated activation (default True)."""
     is_gated = (
diff --git a/test/registered/rl/test_update_weights_from_disk_blackwell.py b/test/registered/rl/test_update_weights_from_disk_blackwell.py
index 78fd977d9..d12676e45 100644
--- a/test/registered/rl/test_update_weights_from_disk_blackwell.py
+++ b/test/registered/rl/test_update_weights_from_disk_blackwell.py
@@ -20,7 +20,7 @@ class UpdateWeightsFromDiskBase:
     model = None
     base_url = DEFAULT_URL_FOR_TEST
     request_timeout = 120
-    update_timeout = 240
+    update_timeout = 120
     idle_timeout = 30
     launch_env = None
     decode_payload = {