diff --git a/python/sglang/srt/layers/deep_gemm_wrapper/configurer.py b/python/sglang/srt/layers/deep_gemm_wrapper/configurer.py
index 65261e33c..b467a153a 100644
--- a/python/sglang/srt/layers/deep_gemm_wrapper/configurer.py
+++ b/python/sglang/srt/layers/deep_gemm_wrapper/configurer.py
@@ -18,9 +18,9 @@ def _compute_enable_deep_gemm():
     sm_version = get_device_sm()
     if (_is_cuda and sm_version < 90) or (_is_musa and sm_version < 31):
         return False
-    # SM120 support (mma.sync block-scale, no TMEM) landed in DeepGEMM#324;
+    # SM120/SM121 support (including GB10) landed in DeepGEMM#324;
     # probe the entry point since installed builds may predate it.
-    if sm_version == 120:
+    if sm_version in (120, 121):
         try:
             from deep_gemm import m_grouped_fp8_fp4_gemm_nt_contiguous  # noqa: F401
         except (ImportError, AttributeError):
@@ -40,7 +40,7 @@ ENABLE_JIT_DEEPGEMM = _compute_enable_deep_gemm()
 
 DEEPGEMM_BLACKWELL = ENABLE_JIT_DEEPGEMM and get_platform().is_sm100
 DEEPGEMM_SCALE_UE8M0 = ENABLE_JIT_DEEPGEMM and (
-    get_platform().is_sm100 or get_device_sm() == 120
+    get_platform().is_sm100 or get_device_sm() in (120, 121)
 )
 DEEPGEMM_NEED_TMA_ALIGNED_SCALES = not (DEEPGEMM_SCALE_UE8M0 or _is_musa)